Jeff Keppinger's broken-bat single in the 10th inning off closer Kevin Gregg gave the Houston Astros a 3-2 victory over the Chicago Cubs on Tuesday night.

Hunter Pence homered and Michael Bourn had an RBI single for the Astros, who carried a 2-1 lead into the eighth before Alfonso Soriano hit a long home run off LaTroy Hawkins.

Ivan Rodriguez opened the bottom of the 10th with an infield single down the third-base line, his first hit with Houston after starting the season 0-for-7. Lance Berkman followed with another single off Neal Cotts (0-1) before Cubs manager Lou Piniella brought in Gregg.

Rodriguez advanced to third when pinch-hitter Jason Michaels flied out to center. Miguel Tejada was intentionally walked, loading the bases for Keppinger, who entered as a pinch-runner in the ninth.

Acquired from Cincinnati last week, Keppinger snapped his bat and stumbled out of the box on his grounder between third and shortstop that scored Rodriguez.

Houston earned its first win of the season after the Cubs won 4-2 on Monday behind Carlos Zambrano.

Aaron Miles reached base with two outs in the top of the 10th on a throwing error by Tejada at shortstop. Doug Brocail (1-0) retired Soriano for the third out.